A Comparison of Injected and Orally Administered β-glucans
نویسنده
چکیده
β-glucans have been extensively studied for their pharmacological effects. Despite in-depth research, little is known about the optimal dose and/or optimal route of application. In this paper, we are reporting the result of comparing the immunostimulating activities of four commercially available glucans differing both in their solubility and source. In addition, we compared intraperitoneal and oral application, and the differences between a single versus repeated doses.
منابع مشابه
Comparison of the effect of orally administered soluble beta-(1-3),(1-6)-D-glucan and of G-CSF on the recovery of murine hematopoiesis.
Beta-glucans are branched fungal polysaccharide compounds with pleiotropic activating effects on cells of the immune and the hematopoietic system. In this study, the hematopoiesis-promoting effect of an orally administered soluble beta-(1-3),(1-6)-D-glucan and of intravenously (i.v.) injected recombinant human granulocyte colony-stimulating factor (G-CSF/filgrastim) was tested in cyclophosphami...
متن کاملAnti-stress action of several orally-given β-glucans.
BACKGROUND β-Glucans are well-established immunomodulators. Recently, glucans have been found to influence stress-related immunosuppression. AIM The aim of this study was to compare the effects of four different types of β-glucans on immune reactions suppressed by cold- or restrain-induced stress. METHODS Mice were subjected to restraint and cold stress for various time intervals. The abili...
متن کاملIrradiated β-glucan enhances immune response to bacterial infection through CD4 and CD8 T-lymphocytes
Background: &beta-glucans are glucose polymers with a variety of stimulatory effects on the immune system. The objective of this study was to evaluate the immune-enhancing activities of low molecular weight gamma irradiated &beta-glucan (I&beta-g) extracted from Pleurotus ostreatus in response to Pseudomonas aeruginosa infection in rats. Materials and Methods: &beta-glucan (&beta-g) powder was ...
متن کاملOrally administered particulate beta-glucan modulates tumor-capturing dendritic cells and improves antitumor T-cell responses in cancer.
PURPOSE The beneficial properties of β-glucans have been recognized for centuries. Their proposed mechanisms of action in cancer therapy occur via stimulation of macrophages and priming of innate neutrophil complement receptor 3 for eliciting complement receptor 3-dependent cellular cytotoxicity of iC3b-opsonized tumor cells. The current study is to investigate whether β-glucan therapy has any ...
متن کاملThe Effects of Orally Administered Beta-Glucan on Innate Immune Responses in Humans, a Randomized Open-Label Intervention Pilot-Study
RATIONALE To prevent or combat infection, increasing the effectiveness of the immune response is highly desirable, especially in case of compromised immune system function. However, immunostimulatory therapies are scarce, expensive, and often have unwanted side-effects. β-glucans have been shown to exert immunostimulatory effects in vitro and in vivo in experimental animal models. Oral β-glucan...
متن کامل